1,2 To the best of our knowledge, there is no existing clinical approach for linear hyperpigmentation diagnosis. The lines of Blaschko represent a pattern followed by many skin disorders. They run down the arms and legs. We. (A) Several small brownish erythema located linearly along Blaschko's line,Electronic address: Margie. A dermatome is an area of skin that is primarily supplied by a single nerve root: communicating sensation from this skin region to the brain. The concept of Blaschko’s lines were first introduced by Alfred Blaschko in 1901. In 1998, when reporting 2 cases of linear childhood CLE following the lines of Blaschko, Abe et al. They were described and drawn by Blaschko 75 years ago. We describe the first reported case of childhood linear DLE following the lines of Blaschko. They never cross the previous truncal middle line But run for it. Most often diagnosed during infancy because of the striking cutaneous findings that typical follow Blaschko lines. Linear atrophoderma of Moulin is a rare subtype of atrophic and pigmented linear morphoea. Three months later, the proband had several verrucous changes ( Figure 1B )], hyperpigmented maculas, and very few vesicles. Blaschko's lines were first described by Alfred Blaschko in 1901 and are thought to reflect patterns of cell migration and clonal expansion during the embryonic development of the epidermis [2. To recap, since 2012 or earlier, waves of social media users searched for “humans have stripes,” “humans have invisible stripes,” or “Blaschko’s lines,” likely landing on Wikipedia’s. This contribution provides an update on the diverse genetic etiologies, cutaneous findings,. British Journal of Dermatology. How To Pronounce Lines composed a few miles above Tintern Abbey, on revisiting the banks of the Wye during a tour, July 13, 1798 How To Pronounce Lines Composed a. These skin cells go rapidly in groups along these Blaschko’s lines as the fetus develops. Incontinentia pigmenti, also known as Bloch-Sulzberger syndrome, is an uncommon sex-linked inherited syndrome reported primarily in females, as it is often lethal to male fetuses in utero. It is solitary in 50% of cases and may follow Blaschko lines. Clinical features are heterogeneous. Thus, the pattern of Blaschko's lines in HI may result from the migration and proliferation of epidermal cells during embryogenesis 17. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. Literature. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. Kawasaki disease (KD) is a self-limited, systemic vasculitis developing in early childhood. . We investigated a female Labrador Retriever and her crossbred daughter, which both showed similar clinical lesions that followed Blaschko's lines. Jun 21, 2020 - Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. Confluent and reticulated papillomatosis is an uncommon skin condition affecting the trunk, neck and axillae. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. Department of Dermatology, Yale University School of Medicine, New Haven, CT. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. A 14-year-old girl, born of a third-degree consanguinous marriage, came to us recently, with multiple grouped pits filled with black plugs over left cheek, left side of. Fig 1 Acne predominantly on the left upper portion of the back at age 15 years. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Finally, we differentiate Blaschko's lines from other. Nevertheless, this should be considered in the differential diagnosis of any macular hyperpigmentation. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. com Open. 2Atrophic, squamous, and erythemato-violaceous plaques following Blaschko’s lines were noted on her left knee . This contribution provides an update on the diverse genetic etiologies. Unilateral LPP with a Blaschko’s line is a unique condition. These lines are named after Dr. The lines of Blaschko represent a pattern followed by many skin disorders. Conclusion: Invisible Lines, Visible Impact. The histopathologic analysis of a skin biopsy in conjunction with the anamnesis allowed the diagnosis of. Close. Introduction: Pigmentary mosaicism (PM) manifests by pigmentation anomalies along Blaschko's lines and represents a clue toward the molecular diagnosis of syndromic intellectual disability (ID). Blaschko's lines are the pattern assumed by different naevoid and acquired skin diseases on the human skin . Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. [French, from past participle of blaser, to cloy, from French dialectal, to be chronically hung over, probably from Middle Dutch blāsen, to blow up, swell; see bhlē- in. The lines do not follow blood vessels, nerves, or other structures in the body. A. Recent studies have suggested that these linear pigmentary anomalies reflect underlying genetic mosaicism. He noticed that about 150 of his patients all had rashes and moles. 1, 2 The nevi are generally unilateral, following Blaschko lines in linear. 2. The lines of Blaschko represent a pattern followed by many skin disorders. Fungus that causes Athlete's. These lines were painstakingly and thoroughly documented first by German dermatologist Alfred Blaschko. The Blaschko’s lines result from the fact that some of a chimera's skin cells say “make darker skin” and some say “make lighter skin. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. were the first to describe a seemingly unidentified entity characterized by the presence of hyperpigmented and atrophic band-like lesions that closely followed Blaschko’s lines []. The major function of this system is as a barrier against the external environment. . Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. These lines may express different amounts of melanin, or become visible due. The archetypal figure has been subsequently updated by others and is represented elsewhere with greater detail in regions such as the head and neck (see Happle and Assim, 2001). Human skin is covered in stripes. Unilateral distribution of lesions in arm, leg. LWNH refers to the swirls and whorls of hyperpigmentation distributed along Blaschko’s lines. There have been many attempts to elucidate the Blaschko's lines on face from the distributional patterns of different nevi, but studies that evaluated exclusively pigmentary nevi are sparse. They were described and drawn by Blaschko 75 years ago. . They were described and drawn by. bla·sé (blä-zā′) adj. Blaschko’s lines are a fascinating part of our genetic code and a reminder of the complexity and diversity of the human body. 1 Linear cutaneous lesions are those that occur along imaginary skin lines like Blaschko’s lines, lymphatics, and blood vessels or those with. in 1998 to reflect the linear nature of the diseaseTo date, there have been 16 documented cases of linear alopecia diagnosed as chronic cutaneous lupus erythematosus occurring in a linear configuration following Blaschko's lines. The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. The term "pigmentary mosaicism" refers to patterned hypo- or hyperpigmentation resulting from a clone of skin cells with altered ability to produce melanin [ 1 ]. As these cells divide and spread over the growing body, they form swirls and streams that create the lines of Blaschko. Case Description Patient 1 A 16-year-old Vietnamese male presented with a 1-year history of hair loss of the scalp. BL are distinct from other patterns such as Voight's lines, Langer's lines of cleavage, and the lines ofThe proband was 2 weeks old at the initial visit, phototype II, presented with vesiculobullous lesions grouped in stripe-like shapes following the lines of Blaschko ( Figure 1A ). Over 100 years later, scientists agree the most likely explanation is that Blaschko lines trace the paths formed during embryonic development, as skin cells migrated and proliferated. Blaschko's lines are the most common pattern of mosaicism. Dermatomes are different from Blaschko lines. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. Blaschko lines presenting as narrow bands are common in mosaic disorders (e. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. Lichen striatus is a rare, benign, self-limited linear dermatosis of unknown origin that predominantly affects children. We have recently observed several cases of linear LP of the face. 24% to 0. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. This characteristic skin lesion. LPP can present concomitantly with other variants of LP such as frontal fibrosing alopecia, as well as endocrinopathies, and autoimmune diseases. A postzygotic mutational event may lead. 2021. genital and are arranged in a linear fashion following Blaschko’s lines. Blaschko's lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Numerous skin conditions, including genodermatoses, nevi, and inflammatory disorders can. Blaschko's lines represent the pathways of epidermal cell migration and proliferation during fetal development. They are often more visible. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the lines of Blaschko. These lines are believed to be a result of the. The lines of Blaschko, which are normally invisible on skin, are thought to follow the paths along which cells migrate as the skin develops before birth. (1987) reported 2 unrelated Japanese children with early-onset reticulate hyperpigmentation distributed in a zosteriform pattern along the lines of Blaschko on the trunk and limbs, but sparing the face, palms, and soles. [7,8] Modified Blaschko's lines proposed by Happle and Assim is currently the most widely accepted one for head and neck area. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. Blaschko Lines in Broad Bands. These lines create a surface pattern which is distinct from other morphological lines. Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. Blaschko's lines refer to the S-shaped or V-shaped whorled, streaked, and linear patterns that are recognized in many different cutaneous disorders. , 2005) and the karyotype of a woman with body asymmetry and patchy skin was mos 45,X/46XX,+14 (Becerra-Solana et al. The lines of Blaschko represent a pattern followed by many skin disorders. (A) Blaschko lines distributed lesions (2-weeks-old). Cutaneous mosaicism does not always follow Blaschko lines, which may relate to the time the mosaicism arises during embryonic development. Antinuclear antibodies (ANA), extractable nuclear antigen (ENA) antibodies (full panel including anti-SSA, anti-SSB, anti-Sm, anti-RNP, anti-Scl-70, anti-Jo-1 and anti-CENP-B), and anti-double stranded DNA (anti. Blaschko’s lines. LPP along Blaschko's lines has been associated with susceptibility to genetic mosaicisms. Blaschko’s Lines. Linear and whorled nevoid hypermelanosis (LWNH) is a rare sporadic pigmentary anomaly, characterized by swirls and streaks of macular hyperpigmentation following the lines of Blaschko, without preceding inflammation, and is usually seen in the first 2 years of life. Conclusions: Our data indicate that linear morphoea follows the lines of Blaschko. One of the subjects developmental biologists are interested in is the development of pattern. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. They were described and drawn by Blaschko 75 years ago. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. The lines of Blaschko were first described in 1901 and represent a pattern that is observed in many skin disorders. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the. Thus, the pattern of Blaschko's lines in HI may result from the migration and proliferation of epidermal cells during embryogenesis 17. 10. Lines similar to ‘Blaschko's lines’ have also been described in eyes and teeth. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. Danarti et al 4 postulated that LAM may reflect the action of an autosomal lethal gene surviving by mosaicism. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. Multiple lesions arise in a linear fashion along the lines of Blaschko, most commonly along a limb or one side of the trunk or head and neck ; Disseminated superficial actinic porokeratosis (DSAP) This is the most common variety and arises in. The shape of Blaschko represent a pattern assumed on many different nevoid and acquired skin diseases on the humanitarian skin and mucosae. We received the patient's consent form about publishing all photographic materials. 62% of all patients with LP [ 1 ]. The lines of Blaschko describe a linear pattern of distribution of various congenital, nevoid, and acquired skin disorders with their suspected embryological origins not yet well understood. It's probably still somewhat confusing, but articles on rare and little-understood medical conditions. , 2008). The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. comedone-like pits coronoid lamellaIn an infant or young child, a nevus sebaceous (sebaceous naevus) presents as a solitary, smooth, yellow-orange hairless patch or plaque, often oval or linear in shape. The lines are V-shaped in the posterior midline (more so on the upper spine), inverted U-shaped on the chest and upper arm, S-shaped on the abdomen, and linear on the legs and lower arms. It is characterised by skin abnormalities in the form of unilateral or bilateral cutaneous macular hypopigmented whorls, streaks and patches, corresponding to Blaschko’s lines. The patches are seen along the Blaschko lines; the lines of Blaschko are invisible lines or patterns on the body along which normal skin cell development tends to occur; The skin patches may appear as irregular streaks or as twisted whorls; Acquired Blaschkoid Dermatitis is typically unilateral - affecting only one side or one half of the body Epidermal nevi occur in one out of 1,000 live births, and 80 percent of cases appear in the first year of life. Pigmentary nevi represent nevi with altered pigmentation. In 1992, Moulin et al. In heterozygous females affected by an X-linked skin disorder, lesions often appear in a characteristic pattern, the so-called Blaschko's lines. Blaschko Lines follow the same pattern on all people. A dermatome is an area of skin that is supplied by a single spinal nerve. 62% of all patients. Alfred Blaschko in 1901 when he examined over 140 patients with linear skin lesions that followed similar patterns. Moreover, the clinical and histopathologic overlap between the entities of blaschkitis and lichen striatus is explored. Epidermal genetic mosaicism due to somatic mutations potentially results in an acquired blaschkitis (skin inflammation on Blaschko's lines) triggered by external. Type 1b Blaschko lines are so broad that it is sometimes difficult to even identify a linear pattern. They were described and drawn by a German dermatologist, Blaschko, more than 100 years ago. The appearance of LPP in our case could not be directly linked to a specific cause because of the ambiguity in the pathogenesis of the disease. 62% of all LP patients. The genetic mosaicism in an acquired Blaschko-linear inflammatory dermatosis could be accountable for the cutaneous antigenic mosaicism that can prompt a mosaic T-cell response based on the trigger of. This contribution provides an update on the diverse genetic etiologies, cutaneous findings, potential associated extracutaneous. They are clinically important, as many inherited and acquired diseases follow these lines, making a characteristic visual appearance. The LCLE is a highly unusual variation of discoid lupus erythematosus (DLE) []. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. Blaschko Lines follow the same pattern on all people. Paul Blaschko, who first described them in the early 1900s. Blaschko’s lines are embryonal, epidermal cell lines distinct from the dermatome, and cutaneous lesions following Blaschko’s lines are a manifestation of cutaneous mosaicism [5]. For easier comparison, a simplified form of the latter that had fewer. Citation 59 On the other hand, blaschkoid LP is differentiated from linear LP, as it adheres to Blaschko’s lines. Here is a partial list of other materials that glow: Petroleum jelly, such as Vaseline, glows a bright blue color under a fluorescent light. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. A case of bilateral linear and annular lupus panniculitis following Blaschko's lines in a childConfluent and reticulated papillomatosis (CARP) is an uncommon dermatosis characterized by hyperpigmented scaly macules or papillomatous papules coalescing into confluent patches or plaques centrally with a reticular pattern peripherally ( picture 1A-D ). Blaschko’s lines on the scalp, and review the literature with an emphasis on this entity’s dis-tinct clinical and histopathologic findings. Introduction. This case presented with mild symptoms of MPS such as hepatosplenomegaly, joint stiffness, and quite mild bone deformity, which was the reason for the delay in diagnosis until the age. In 55 (85%) children the skin lesions were confined to one side of the body, showing no preference for either left or right side. Lines of Blaschko are usually invisible unless genetic mutations result in mosaicism that alters the pigmentation, proliferation, and/or differentiation of epidermal cells. Two years later, Baumann et al. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. It is not present at birth, hence the term 'acquired'. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. Blaschko lines track distinct patterns (Figure 3). The visual appearance of X-linked skin disease can follow the pattern of lines described by the dermatologist Alfred Blaschko. Many nevoid skin lesions display an arrangement following these lines. Blaschko's Lines. 24%-0. The human stripes are visible only under UV light but invisible to th. Blaschko’s lines were originally described by Dr. They may be either visible at birth or become manifest dur - ing the first years of life. Blaschko Lines are common skin patterns that were first identified in 1901 by a German dermatologist named Alfred Blaschko. We described herein an 18-month-old male patient with KD who presented with linear, facial erythema coinciding with Blaschko’s lines. Blaschko’s lines. Mosaic individuals are composed of two. Citation 58 Linear or zosteriform LP is an uncommon variant that follows the Koebner phenomenon, does not adhere to Blaschko’s lines, and rarely follows a dermatomal arrangement. They are named after German dermatologist Alfred Blaschko, who first described them in 1901. Blaschko’s lines were originally described by Dr. Since then, several additional cases. Blaschko's lines refer to the S-shaped or V-shaped whorled, streaked, and linear patterns that are recognized in many different cutaneous disorders. The stripes on humans are called Blaschko’s lines,. The patient was diagnosed with SV along Blaschko's lines (Fig. Incontinentia pigmenti (IP; Bloch-Sulzberger syndrome, MIM #308300) is an X-linked dominant genodermatosis that is usually lethal in males before birth [ 1-4 ]. To our knowledge, the dermatoscopic features of pigmented lesions in LWNH have not been described previously. 5 months. Finally, there is a rare atrophic variant of LP [1], [2]. Method: One hundred eighty-six figures showing skin lesions following Blaschko's lines on the head and neck were collected from literature. Follows Blaschko’s lines; Streaks and whorls; Fades in adolescence; The third incontinentia pigmenti stage is the hyperpigmented stage in which the skin is darkened in a swirled pattern often described as a “marble cake” appearance. 2) 3. Over the course of years of examining thousands of patients, he often observed people who exhibited unusual patterns of dark stripes and swirls that encompassed their entire bodies. 4% of cases of pediatric lichen planus were linear along the lines of Blaschko; this subvariant. These lines are unique and rarely found in nature and are a result of abnormal cell migration during development in the womb. Yeah, there were multiple things of vanilla ice cream and now they're one thing, but it's all vanilla ice cream. According to the affected skin com-ponents, epidermal nevi have been divided into organoid (with abnormal adnexal components, such as the hair follicles, seba-Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. Congenital lesions may include incontinentia pigmenti and variants of epidermal nevi. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Lichen striatus is an acquired inflammatory dermatosis that follows the lines of Blaschko. Full size image. 1 Because many skin disorders that followed these lines were present at birth, Blaschko suspected that they had an embryonic origin. The lines of Blaschko represent a pattern followed by many skin disorders. A healthy 7-year-old girl presented to our clinic with bilateral asymmetric LS occurring on the right arm and left leg of 1-year duration. Hyper-pigmented streaks following the lines of Blaschko, the result of a genetic mutation found in some skin cells but not others. Blaschko lines are consistently V-shaped on the upper spine, S-shaped on the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. In our case, the cytogenetic analysis on peripheral blood. (B) verrucous formation on the middle digit (3-months-old). In our case, the cytogenetic analysis on. We do however hope that visitors to this site can contact us regarding comments that are considered. The present CME article will highlight important. have reported the case of a 48-year-old patient with three clinical subtypes [ 12 ], while Vineet et al. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. Blaschko's lines have so far been known as hypothetical lines that represent the migration lines of the embryonic cells like primitive melanoblasts from the neural crest to skin. When we start out as a single cell, and then a ball of cells, some of these cells become skin cells. They can be macular or with some elevated component that may develop. [] It is usually unilateral and single, although bilateral or multiple LS have been previously reported in the literature. Unlock premium audio pronunciations. In fact, these are leftover from the time the person was a baby growing in the womb. Physical examinationConfluent and reticulated papillomatosis (CARP), also called confluent and reticulated papillomatosis of Gougerot and Carteaud, is an uncommon skin condition that consists of multiple small, hyperkeratotic macules or papules that coalesce to form patches or plaques with a reticulated (net-like) pattern peripherally. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Blaschko's lines, also called the Lines of Blaschko, are an extremely rare and unexplained phenomenon of human anatomy first presented in 1901 by German dermatologist Alfred Blaschko. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. Blaschko. French dermatologists Gourgerot and Carteaud first described confluent and reticulated papillomatosis in 1927 [1]. These lines are invisible under normal conditions. Like dermatomes, they are linear on the limbs and circumferential on the trunk. The cause of lichen striatus is unknown. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. These lines are typically invisible to the naked eye, but they form distinct patterns on the body. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. 3A 27-year-old Japanese woman presented with small atrophic hyperpigmented macules on her extremities since early childhood. Of all ACC cases, 70% are single lesions, 20% are double, and 8% are triple. Blaschko: Die Neven-verteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut. These lines are invisible under normal conditions. The Stripes on Humans: An Exploration. These lines are named after Dr. Mosaicism describes an individual composed of two or more genetically different. 5 These lines are curved over scalp. The lines of Blaschko represent a pattern assumed by several different nevoid and acquired skin diseases at the human skin and mucosae also do non match to any known nervous, vascular or lymphatic structures. Blaschko lines correlate with mosaicism, regardless of the clinical presentation. Blaschko's lines form a pattern, which many diseases are found to follow, but linear scleroderma following Blaschko's lines is a controversial entity rarely reported in the literature. Uranium glass or vaseline glass. SUMMARY. She showed small-sized or aplastic fingernails on the right hand. Like dermatomes, they are linear on the limbs and circumferential on the. Lines of Blaschko doi: 10. These lines are invisible under normal conditions. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. Keywords. Various chromosomal anomalies have been identified in. Acquired blaschkoid dermatitis is unilateral — it only affects one side of the body. Prior to our report, a case of segmental and non-segmental vitiligo followed by Blaschko lines was never described, therefore we suggest the term "mixed vitiligo of Blaschko lines" to describe this entity. ” No conditions following Blaschko's lines in narrow bands had a genetic abnormality. A diagram of the distribution pattern of these lines has since been drawn and is now referred to as the lines of Blaschko. Lesions can appear anywhere, but the sites most commonly affected are the fingers and wrists, axillae, groin, and genitalia, and the skin around the eyes and mouth. In conclusion, Blaschko's lines are a testament to the hidden complexities of the human body. The BL were described and drawn by Alfred Blaschko, a German dermatologist, in 1858-1922 [ 1, 2 ]. Last updated October 06, 2023. T-lymphocyte migration and clonal expansion in the course of embryogenesis of the skin could express the appearance of Blaschko’s lines. In the present instance, the linear erythema resolved promptly in response to primary IVIG therapy as with the other KD symptoms, suggestingThese preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if detectable, is best shown in keratinocytes; and (3) the cytogenetic defect in epidermal cells may be directly responsible for the failure of pigmentation in HI. ream@nationwidechildrens. In 1901, the German dermatologist Alfred Blaschko described a system of cutaneous lines that represented the typical pattern that linear nevi appeared to follow. 00021-4. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. 5474 Linlin Bao 1,2 , Zhaojun Sun 1,2 , Fang Yang 1,2Hypomelanosis of Ito is a rare neuroectodermal disorder often associated with mental retardation and epilepsy. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. Lichen striatus is clinically diagnosed on the basis of its appearance and characteristic developmental pattern following the. in 1986. The nowadays well-known lines of Blaschko form streaks displaying a V-shape or fountain-like pattern on the back, an S-shape or whorled pattern over the lateral aspects of the trunk, and a linear pattern on. These lines are consistently S-shaped on the abdomen, V-shaped on the upper spine, perpendicular along the length of the arms and legs, inverted U-shaped on the chest, and follows a more. They curve around the sides, like tiger stripes. Disorders with a neuronal origin follow this pattern of distribution. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large. Blaschko line, lichen planus, Blaschkoian lichen planus, zosteriform lichen planus. In this study, we investigated clinical features and treatments of LPS by literature review of articles in the English language from PubMed and SCOPUS databases up to April 2018. 62% of all patients. They represent lines of division of the two cell lines within the embryonic skin tissue. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large. Blaschko's lines also termed as the lines of Blaschko, are believed to represent normal cell development in the skin. Herein, we report a patient with patterned cutaneous hypopigmentation with a similar phenotype due to a novel. (B) verrucous formation on the middle digit (3-months-old). He was otherwise healthy with no family history of au-toimmune diseases. Unconcerned; nonchalant: had a blasé attitude about housecleaning. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Numerous skin conditions, including genodermatoses, nevi, and inflammatory disorders can present along Blaschko lines. It is also important to mention that not all XX/XY individuals are chimeras. [2,3] In contrast to dermatomes, Blaschko's lines form a V-shape over the spine and an S-shape on the lateral and anterior aspects of the trunk. The eruption is. They never cross the anterior truncal midline but run along it. Blaschko线是以首次描述这些线的人名字命名的。. These lines, which form V patterns on the back and S patterns on the stomach, are a consequence. Understanding the origins and significance of these lines can provide insights into the development and growth of the human body. Multiple organ systems can be involved. In this paper, we presented a 47. They were described and drawn by Blaschko 75 years ago. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. In IP patients with neurological signs brain lesions usually were localized and extended radially. Articles were analyzed in which brain imaging methods were used in IP patients with CNS anomalies. Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. This condition is an inflammatory skin condition resembling dermatitis or eczema and presents with dry, red irritable skin lesions. 24%-0. She had no other. They may be unilateral in early non-segmental vitiligo, or in segmental vitiligo when confined to part or all of one or more dermatomes or areas delineated by Blaschko's lines. Acquired Blaschkoid lesions include rare reports of psoriasis, atopic dermatitis, lupus erythematosus, fixed drug eruption, graft-versus-host disease, and erythema multiforme. Moderate papillary dermal edema was present, along with focal homogenization of the collagen and. Expand [PDF] Save. There have been many reports of congenital and acquired. [] However, some cases of LS showing bizarre. CHARGE syndrome is a congenital condition (present from birth) that affects many areas of the body. different dermatoses, but the cause of this Revised version accepted 3 June 1993. This contribution provides an update on the diverse genetic etiologies. Blaschko's lines represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. Blaschko's lines. Gov't. Method: One hundred eighty-six figures showing skin lesions following Blaschko's lines on the head and neck were collected from literature and patient files,. (C) Blaschko linear, erythematous and pigmented atrophic line with a verrucous part (6-months-old). The objective of this study was to consider a hypothesis of the existence of Blaschko lines in the CNS in the example of incontinentia pigmenti (IP). The most frequent variant of LPP is linear, as was observed in the current case, with zosteriform or Blaschkoid LPP being much less common. The lines of Blaschko were originally described by Alfred Blaschko in 1901. It depends on their location. The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. The initial appearance was reddish hyperkeratotic. 5 The distribution of LPP along the Blaschko lines was first described by Taniguchi et al. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. lines of Blaschko: ( blahs'kō ), a pattern of distribution of skin lesions or pigmentary anomalies; linear on the extremities, S-shaped curves on the abdomen, and V-shaped. Blaschko's lines. This contribution provides an update on the diverse genetic etiologies.